The reference site for Mexiletine

Mexiletine (INN) (sold under the trade name Mexitil) is a non-selective voltage-gated sodium channel blocker which belongs to the Class IB anti-arrhythmic group of medicines.

WHAT IS Mexiletine?

Mexiletine belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart, or seriously irregular heartbeats.

This medicine affects the way that the heart beats. It works by slowing nerve impulses in the heart and making the heart tissue less sensitive.

Mexiletine is sold under the trade name Mexitil®.

 

Brand Name(s): Mexitil
CAS nº: 31828-71-4
(mex ILL eh teen)

 

Product Info

The sections below will provide you with more specific information and guidelines related to mexiletine and its correct use. Please read them carefully.

FDA Information

Mexiletine was approved by the FDA in December 1985, and its patent expired in June 1994.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Mexiletine is an antiarrhythmic agent (class IB). This medication is used to treat irregular heart rhythm, and can also slow rapid heartbeats (tachycardia).

This medicine affects the way that the heart beats. It slows nerve impulses in the heart by helping it to return to and maintain a normal rhythm.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Mexiletine is available in injection and capsule form.

Take mexiletine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each capsule dose with a full glass of water. You can also take this medication with food or an antacid to lessen stomach upset.

Do not skip any doses, change your dosing schedule, or stop taking mexiletine without first consulting your doctor. Changing your schedule could make your condition much worse.

What special precautions should I follow?

BEFORE TAKING MEXILETINE:

Tell your doctor if you have any other type of heart disease or heart problem, liver disease, seizures or epilepsy. You may not be able to take this medicine, or you may require a lower dose or special monitoring during treatment, if you have any of the conditions listed above.

Tell your doctor if you are taking any of the following medicines: phenytoin (Dilantin®), mephenytoin (Mesantoin®), or ethotoin (Peganone®); rifampin (Rimactane®, Rifadin®); metoclopramide (Reglan®); cimetidine (Tagamet®, Tagamet HB®); or theophylline (Theo-Dur®, Theolair®, Elixophyllin®, Slo-Phyllin®, others). You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with mexiletine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Please note that mexiletine is in the FDA pregnancy category C. This means that it is not known whether this medicine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Furthermore, mexiletine passes into breast milk. It is not known whether this medicine will affect a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Use cautiously when driving, operating machinery, or performing other hazardous activities. Mexiletine may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, try to avoid these activities.

Follow any other special instructions your doctor gives you regarding food, beverages, or activities.

What should I do if I forget a dose?

Try not to miss any doses of this medication. Missing doses could be very dangerous.

If you do miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose.

Never take a double dose of this medication. Taking a double dose could also  prove to be dangerous.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking mexiletine and seek emergency medical attention:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives)
a new or a worsening irregular heartbeat pattern
wheezing, coughing, chest pain, or chest discomfort
unusual bruising or bleeding
fever
sore throat or mouth
mouth ulcers or an infection

Other, less serious side effects may be more likely to occur. Continue to take mexiletine and talk to your doctor if you experience

dizziness, lightheadedness, or tiredness
poor coordination
dry mouth
upset stomach, heartburn, vomiting, or decreased appetite
diarrhea or constipation
headache or blurred vision
weakness
numbness, tingling, or tremor (shaking)
ringing in your ears
a rash
depression

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If you have any questions, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services on 911.

Symptoms of overdose may include:

nausea
seizures
numbness or tingling
tiredness
dizziness
a loss of consciousness
a worsening irregular heartbeat

Product Images

PICTURES OF MEXILETINE PRODUCTS

Below you will find images and specific information on the principal types of mexiletine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: MEXILETINE
Strength(s): 150 MG
Imprint: 54 523
Manufacturer: ROXANE LABS.

Name: MEXILETINE
Strength(s): 150 MG
Imprint: N 739 | 150
Manufacturer: TEVA USA

Name: MEXITIL®
Strength(s): 150 MG
Imprint: MEXITIL 150 MG | BI 66
Manufacturer: BOEHRINGER ING.

Name: MEXILETINE
Strength(s): 200 MG
Imprint: N 200
Manufacturer: NOVO

Name: MEXILETINE
Strength(s): 200 MG
Imprint: N 740 | 200
Manufacturer: TEVA USA

Name: MEXITIL®
Strength(s): 200 MG
Imprint: MEXITIL 200 MG | BI 67
Manufacturer: BOEHRINGER ING.

Name: MEXILETINE
Strength(s): 250 MG
Imprint: N 741 | 250
Manufacturer: TEVA USA

Name: MEXITIL®
Strength(s): 250 MG
Imprint: MEXITIL 250 MG
Manufacturer: BOEHRINGER ING.

Name: MEXITIL®
Strength(s): 250 MG
Imprint: MEXITIL INJECTION
Manufacturer: BOEHRINGER ING.

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